Nickelodeon extensively promoted the show across all of their networks, using a musical infomercial sung by Grover.

The show was heavily linked with Noggin's website,, and it featured a regular segment where computer games from Noggin were played. Play with Me Sesame premiered on Apand ran for three seasons. Many of the background designs in Play with Me Sesame were simultaneously used in Nickelodeon's Moose and Zee interstitials. Kidscreen reported that 'the series marks the first time a State-side entity other than Sesame Workshop has been given permission by Henson to use the Sesame Street Muppets.' Noggin shot footage of the characters on a green screen, and animators at Nick Digital added in new graphics.

To start production, Nickelodeon had to seek approval from Henson. The show began development in 1999, when the Jim Henson Company still co-owned the rights to the Sesame characters. To do this, they combined classic Sesame Street footage with new segments, where the hosts invite preschoolers to join them in games. Nickelodeon and Sesame developed the show to expand on Sesame Street by directly encouraging young viewers to interact with the characters. The series' backgrounds and animated elements were made by Nickelodeon Digital in New York City. It is a spin-off of Sesame Street hosted by Ernie, Bert, Prairie Dawn, and Grover. Play with Me Sesame is an American children's television series, created by Sesame Workshop and Nickelodeon for their former joint venture Noggin.

Play with me sesame youku